N-Acetylcysteine

N-Acetylcysteine ​​(NAC) is a non-essential amino acid, meaning that the body can synthesize it from other amino acids. However, it can also be obtained through food or supplementation. NAC plays a fundamental role in several biological processes, particularly in the production of glutathione , an essential protein.

In this article, we'll explore what N-acetylcysteine ​​is, its close relationship with glutathione, and the interesting synergy it creates with black pepper . We'll also guide you through choosing the perfect supplement by offering a detailed buying guide to help you make an informed choice.

What is N-Acetylcysteine ​​(NAC)?

N-Acetylcysteine ​​(NAC) is a stabilized form of cysteine , an amino acid important for several functions in the body. Unlike cysteine, which is fragile and degrades quickly, NAC is more stable , making it easier for the body to absorb and use .

Once ingested, NAC readily converts to cysteine, which is then used to produce glutathione , a protein. Although the body can produce cysteine ​​from methionine (another amino acid), sufficient NAC intake allows for the production of cysteine ​​and, therefore, glutathione.

NAC is present in several vital organs such as the liver , lungs , kidneys , and brain . Although not directly present in food, cysteine ​​is found in protein-rich food sources such as:

• Meats (beef, poultry),
• Fish and seafood,
• The eggs,
• Dairy products (cheese, milk),
• Legumes (lentils, beans),
• Nuts and seeds.

These foods provide the amino acids needed for the production of glutathione.

N-Acetylcysteine ​​and glutathione

One of the most important roles of N-Acetylcysteine ​​(NAC) in the body is its ability to facilitate the absorption and utilization of cysteine , due to its more stable form than cysteine ​​itself. Once released into the body, cysteine ​​plays a role in the production of glutathione .

What is glutathione?

Glutathione is a protein composed of three amino acids: glutamine , glycine , and cysteine . This protein is naturally present in almost every cell in the body , with particularly high concentrations in organs such as the liver , lungs , brain , and kidneys .

These vital organs are involved in many processes essential for the proper functioning of the body:

• The liver : Filters the blood, removes toxins, breaks down harmful substances, and helps digest fats.
• The lungs : Allow the exchange of oxygen and carbon dioxide.
• The brain : Controls bodily functions, including thinking, memory, and managing emotions.
• Kidneys : Filter waste from the blood, regulate electrolyte balance and blood pressure.

Why is it important to maintain good glutathione levels?

Adequate glutathione levels are essential for the body to function properly . However, several factors can cause a decrease in natural glutathione production, including:

• Aging ,
• Exposure to pollutants ,
• Intense physical activity .

This is why consuming NAC is important: it provides additional cysteine , which is needed to maintain optimal glutathione levels.

N-Acetylcysteine ​​and black pepper: an interesting synergy

In many dietary supplements, N-Acetylcysteine ​​(NAC) is combined with an ingredient that is well known in cooking, but whose health benefits are often underestimated: dry black pepper extract , scientifically known as Piper nigrum L.

What is black pepper?

Black pepper is a spice obtained from the dried berries of the pepper plant, a plant of the Piperaceae family, native to India. Used for centuries, it is widely used throughout the world, not only to enhance the flavor of dishes, but also for its interesting properties.

Black pepper contains an active compound called piperine , which plays a key role in optimizing the absorption of certain nutrients.

Why combine NAC and black pepper extract?

The combination of N-Acetylcysteine ​​(NAC) and black pepper extract has interesting benefits for optimizing their action in the body. Cysteine , although naturally produced by the body, can sometimes be insufficient, especially in cases of increased needs. NAC then helps increase cysteine ​​levels to support glutathione production.

The addition of black pepper extract , and more specifically piperine , in this combination supports the absorption of NAC.

Additionally, piperine has several additional benefits:

• Vitalizes the nervous system ,
• Helps cleanse the liver and support its function (by promoting blood circulation through the capillaries and small blood vessels),
• Helps maintain natural digestive functions .

Thus, this synergy between NAC and black pepper not only enhances the effectiveness of supplementation, but it also supports crucial bodily functions.

Where can you find this combination?

More and more dietary supplement brands are now offering formulas combining N-Acetylcysteine ​​and black pepper extract . When purchasing, it is advisable to check:

• The exact dosage of black pepper extract (usually around 0.10 mg),
• And the overall quality of the product (absence of additives, certifications, traceability).

Buying Guide: How to Choose a Good NAC Supplement?

When looking for an N-Acetylcysteine ​​(NAC) supplement, it's important to pay attention to several criteria to ensure you choose a quality product that's right for your needs. Here are some tips to help you make your choice:

1. NAC Form : NAC is often available in capsule form, which is convenient to ingest and provides accurate dosing. This form is ideal for daily supplementation, allowing you to follow the supplier's recommended dosage.
2. Check the concentration : It is essential to check the concentration of NAC in each dose. Depending on your needs, common doses generally range from 300 mg to 1200 mg per day. Ensure the product you choose matches the desired dose for optimal effectiveness.
3. Examine the ingredients : Look for products that don't contain unnecessary additives . Some supplements add black pepper extract, which is a good combination .
4. Choose reputable brands : Choose trusted brands that adhere to strict quality standards and offer complete transparency regarding the origin and manufacturing of their products. A well-known brand generally guarantees you a good quality supplement.
5. Check reviews and certifications : Before purchasing, check consumer reviews and quality certifications. This will give you insight into the effectiveness and safety of the product you are considering.

By following these criteria, you will be able to choose a NAC supplement adapted to your needs and guaranteed to be of quality.

Side effects and precautions

N-Acetylcysteine ​​(NAC) is generally considered safe when taken as directed. However, as with any supplement, side effects can occur, including gastrointestinal upset in some people. Therefore, it is crucial to stick to the recommended doses to avoid any risk of discomfort.

Additionally, before starting any NAC supplementation , it is strongly recommended to consult a healthcare professional , especially if you have any pre-existing medical conditions or are taking any medication. This helps ensure that supplementation does not pose any risk to your health and allows you to adjust the doses according to your specific needs.

Conclusion

N-Acetylcysteine ​​(NAC) , combined with ingredients like black pepper extract, makes for an interesting dietary supplement with many health benefits. However, as with any supplement, it is essential to use it responsibly and with knowledge .

Before starting NAC supplementation, especially when combined with black pepper, it is recommended to consult a healthcare professional . This will help personalize the supplementation according to your needs and ensure its safe integration into your routine.

Source :

1. Haq, I., Imran, M., Nadeem, M., Tufail, T., Gondal, TA, Mubarak, MS (2020). Piperine: A review of. DOI: https://doi.org/10.1002/ptr.6855 .