Glycine, a non-essential amino acid, is a fundamental component of proteins. Known for its multiple biological roles, it is particularly valued by athletes for its numerous benefits.
Here, we will explore the advantages of glycine for improving physical performance and supporting recovery.
What is glycine?
Definition and history
Glycine, also known as aminoacetic acid, is one of the 22 proteinogenic amino acids, essential for protein formation in the body.
It was first isolated by French chemist Henri Braconnot in 1820. Glycine takes its name from the Greek "glykys," meaning "sweet," due to its sweet taste. Today, it is produced industrially from chloroacetic acid and ammonia.
Unique characteristics
Unlike most other amino acids, glycine is non-chiral, meaning it does not have an asymmetric carbon. This characteristic distinguishes it and simplifies its notation, without the "L-" prefix commonly used for other amino acids.
Biological functions of glycine
Collagen synthesis
Glycine is fundamental for the synthesis of collagen, the most abundant protein in the human body. Collagen is essential for maintaining the structure and strength of bones, cartilage, tendons, and ligaments.
By stimulating collagen production, glycine contributes to the regeneration of connective tissues and joint health, which is particularly beneficial for athletes subjected to intense physical exertion.
Bile acid metabolism
Glycine is involved in the formation of bile acids, necessary for the digestion and absorption of fats.
By conjugating with bile salts, it helps make these compounds more soluble, thus facilitating their excretion and participating in liver detoxification, making it an excellent liver supplement.
Precursor of bioactive compounds
Glycine is an important precursor to several biologically active compounds, including creatine, porphyrins, glutathione, acetylcholine, and uric acid.
Each of these compounds participates in important metabolic processes, from oxygen transport to antioxidant protection, as well as nervous and muscular function.
Regulation of homocysteine metabolism
One of the notable benefits of glycine is its ability to regulate homocysteine levels in the blood. Homocysteine, an amino acid derived from methionine, can be harmful at high concentrations.
Glycine helps reduce homocysteine levels, maintaining your cardiovascular fitness and acting to prevent complications related to excessive animal protein consumption.
The benefits of glycine for athletes
Muscle development and recovery
Glycine is widely recognized for its positive effects on muscle mass. By promoting protein synthesis and increasing the secretion of growth hormone, it helps muscle building. After exercise, glycine aids in muscle fiber reconstruction, thus accelerating recovery and reducing muscle fatigue.
Joint protection
As a component of collagen, glycine plays an important role in joint protection. As a joint supplement, it helps maintain the integrity of tendons and ligaments, thereby reducing the risk of injuries related to intense physical activity.
Athletes benefit from better joint resilience and faster recovery after training.
Improved sleep quality
Studies have shown that taking glycine before bedtime improves sleep quality. By acting as an inhibitory neurotransmitter, it helps regulate nerve impulses, thus promoting restorative sleep.
Good sleep is essential for physical recovery and improving your athletic performance.
Antioxidant effects
Glycine participates in the synthesis of glutathione, an extremely powerful and important antioxidant for the body.
Glutathione protects cells against oxidative damage, thus reducing inflammation and oxidative stress caused by intense exercise. This contributes to the recovery and general health of athletes.
Dietary sources of glycine
Glycine, as a non-essential amino acid, is present in many foods, mainly those rich in protein.
These natural sources allow you to incorporate this vital amino acid into your daily diet, thus offering various benefits for health and physical performance.
Meats and poultry
Meats and poultry are among the best sources of glycine. Beef, chicken, and pork contain significant amounts of this amino acid due to their richness in collagenous proteins.
- Beef: Beef is a major source of glycine, especially cuts rich in connective tissue such as shank and marrow bones. These parts are often used to prepare collagen-rich broths.
- Chicken: Glycine is abundant in chicken, particularly in the skin and cartilaginous parts. Chicken broth, prepared with bones and skin, is an excellent source of glycine.
- Pork: Like beef and chicken, pork contains glycine, especially in cuts like pork feet and bones used for broths.
Fish
Fish, especially fatty fish, are also good sources of glycine. Fish contain collagenous proteins that provide this amino acid.
- Salmon: Salmon is not only rich in omega-3s, but also in glycine, contributing to muscle and joint health.
- Tuna: Tuna, especially canned tuna, is a convenient source of glycine.
- Other fatty fish: Fish like mackerel and trout also provide notable amounts of glycine.
Dairy products
Dairy products, although less rich in glycine compared to meats, nevertheless contribute to the overall intake of this amino acid.
- Milk: Both whole milk and skim milk contain glycine, although concentrations are moderate.
- Yogurt: Yogurt, especially Greek yogurt, is a source of glycine due to its high protein content.
- Cheese: Cheeses like cheddar, parmesan, and mozzarella also provide glycine.
Legumes
Legumes are an excellent source of plant-based protein and glycine, ideal for those following a vegetarian or vegan diet.
- Peas: Green peas and split peas are rich in glycine.
- Lentils: Lentils, whether green, red, or brown, provide a good amount of glycine.
- Beans: Red, black, and white beans are also important sources of this amino acid.
Cereals
Whole grains, such as wheat and corn, contain glycine, although their concentrations are generally lower than those of meats and fish.
- Wheat: Whole wheat and its derivatives, such as whole grain bread and pasta, contribute to glycine intake.
- Corn: Corn, in grain or flour form, is another source of glycine.
Vegetables
Some vegetables, although not as rich in glycine as animal sources, nevertheless offer notable amounts of this amino acid.
- Spinach: Spinach is a plant source of glycine and other beneficial nutrients.
- Cabbage: Green cabbage and kale contain glycine.
- Parsley: Parsley, often used as a garnish, is also a source of glycine.
Glycine supplements
To maximize the benefits of glycine, especially for athletes seeking to improve their performance and recovery, taking glycine as a health supplement is an effective alternative.
These supplements provide concentrated doses of glycine without the extra calories of protein-rich foods. Supplements are available in powder or capsule form, offering you flexibility when it comes to choosing your method of consumption.
Dosage and use
Recommended dosage
Glycine dosage depends on individual goals. For athletes, a dose of 5 to 10 grams per day is generally recommended, divided into several doses throughout the day, particularly before and after exercise.
For people looking to improve their sleep, a dose of 3 grams of glycine before bedtime is generally prescribed.
Practical use
Glycine is available in powder or capsule form. It can be taken with water or mixed with a protein drink. It is recommended to consume it with meals to promote its absorption.
To maximize its effects, it is advisable to combine it with B vitamins, which facilitate its assimilation.
Glycine is an amino acid with multiple benefits, particularly appreciated by athletes for its effects on muscle growth, recovery, and joint protection.
By integrating glycine into your diet or as a supplement, you can improve your performance and overall well-being. As with any supplement, it is essential to follow dosage recommendations and consult a healthcare professional before starting a new supplementation.
Sources:
- Plimmer, R.H.A. "The chemical composition of the proteins." Longmans, Green and Co., 1912. : https://www.science.org/doi/10.1126/science.36.925.374.b
- Brind, J., et al. "Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats." : https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.25.1_supplement.528.2
- Inagawa, K., et al. "Subjective effects of glycine ingestion before bedtime on sleep quality." Sleep and Biological Rhythms, 2006. : https://www.researchgate.net/publication/230167843_Glycine_ingestion_improves_subjective_sleep_quality_in_human_volunteers_correlating_with_polysomnographic_changes
- Fukada, S., Shimada, Y., Morita, T., Sugiyama, K. "Suppression of methionine-induced hyperhomocysteinemia by glycine and serine in rats." Biosci Biotechnol Biochem, 2006. : https://pubmed.ncbi.nlm.nih.gov/17031061/
- Wang, W., et al. "Glycine metabolism in animals and humans: implications for nutrition and health." Amino Acids, 2013. : https://pubmed.ncbi.nlm.nih.gov/23615880/
- Heresco-Levy, U., et al. "High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia." Biol Psychiatry, 2004. : https://pubmed.ncbi.nlm.nih.gov/14732596/
- Li, C., et al. "Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine." J Biol Chem, 2013. : https://pubmed.ncbi.nlm.nih.gov/23266825/
- Hasler, G. et al. "Reduced Prefrontal Glutamate/Glutamine and -Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy." Archives of General Psychiatry, 64 (2): 193-200, 2007. : https://pubmed.ncbi.nlm.nih.gov/17283286/